Author

Matthew D. Newton

The Francis Crick InstituteORCID 0000-0002-9453-6791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Evolutionary Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:C. elegans· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:DNA methylation· 1 Research Focus:phylogenetics / evolution· 1 Approach:statistical model· 1

Frequent Co-Authors

Simon J. BoultoniD· 2 shared Alice L. B. PyneiD· 1 shared Antonio ValdésiD· 1 shared Ataya Sathirachinda· 1 shared Aurélien RichaudiD· 1 shared Brandt F. EichmaniD· 1 shared Briana H. GreeriD· 1 shared Carlos Caurcel· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

Simon J. BoultonORCID

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Author profile →

4 papers

Recent·Most cited

TRF2 mediates force-resistant bridging of distal telomeric DNA repeats

Matthew D. Newton, Thomas E. Catley, Sylvia Whittle, Lorenzo Galanti, Laura Louise Wiggins, Elizabeth P. Holmes, Dima Daccache, Roopesh Anand, Ellen G. Allwood, Mark Greensill, Sandra Segura‐Bayona, Ondrej Beláň, Max C. Gamill, Sarah Maslen, Mark Skehel, , Simon J. Boulton

This study shows TRF2 mediates force-resistant tethering of telomeric DNA repeats, which may be a step in T-loop formation.

bioRxiv · Oct 11, 2026 · PreprintBiophysics

Binding Kinetics Oppositely Regulates type II Topoisomerase Relaxation and Decatenation Activities

Cleis Battaglia, Filippo Conforto, Yair Augusto Gutiérrez Fosado, Matt Newton, Erin Cutts, Davide Michieletto, Antonio Valdés

This study shows that topo II binding kinetics oppositely regulate decatenation and relaxation activities through a trade-off between search efficiency and processivity.

bioRxiv · Dec 11, 2025 · PreprintBiophysics

HLTF Prevents G4 Accumulation and Promotes G4-induced Fork Slowing to Maintain Genome Stability

Gongshi Bai, Theresa Endres, Ulrike Kühbacher, Valentina Mengoli, Briana H. Greer, Emma M. Peacock, Matthew D. Newton, Tyler H. Stanage, Maria Rosaria Dello Stritto, Roxana Lungu, Magdalena P. Crossley, Ataya Sathirachinda, David Cortez, Simon J. Boulton, Petr Ćejka, , Karlene A. Cimprich

This paper shows that HLTF has two roles in managing G4s: preventing their accumulation and slowing replication forks to maintain genome stability.

Molecular Cell · Aug 1, 2024Peer-reviewedMolecular Biology

Comparative genomics of ten new Caenorhabditis species

Lewis Stevens, Marie-Anne Félix, Toni Beltran, Christian Braendle, Carlos Caurcel, Sarah Fausett, David Fitch, Lise Frézal, Taniya Kaur, Karin Kiontke, Matt D. Newton, Luke M. Noble, Aurélien Richaud, Matthew V. Rockman, Walter Sudhaus, Mark Blaxter

The paper describes ten new Caenorhabditis species, presents their genome sequences, and analyzes their evolutionary relationships and gene structure.

bioRxiv · Aug 30, 2018 · PreprintEvolutionary Biology