Dustin P. Fykstra

This study identifies GPR182 as a key mediator of lipid deposition in atherosclerosis and shows that its inhibition reduces aortic lipid uptake and disease progression.

This study shows microglia drive myelin loss in MS through autoantibodies and BTK signaling, with implications for therapeutic targeting.

This study identifies GPR182 as a lipoprotein receptor that mediates dietary fat absorption and shows its role in obesity resistance.

This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.