XIST ribonucleoproteins promote female sex-biased autoimmunity
Diana R. Dou, Yanding Zhao, Julia A. Belk, Yang Zhao, Kerriann M. Casey, Derek C. Chen, Rui Li, Bingfei Yu, Suhas Srinivasan, Brian T. Abe, Katerina Kraft, Cecilia Hellström, Ronald Sjöberg, Sarah Esther Chang, Allan Feng, , Howard Y. Chang
This study shows that Xist ribonucleoprotein complexes drive sex-biased autoimmunity in males, leading to autoimmune pathology and reprogramming of immune cells to resemble female patterns.
Cell · Feb 1, 2024Peer-reviewedMolecular Biology