Alison L. Pidoux

The paper shows that heterochromatin epimutations in fission yeast cause mitochondrial dysfunction and antifungal resistance by repressing genes involved in mitochondrial function.

This paper presents a high-quality reference genome for S. osmophilus, a newly identified fission yeast species, and uses it to conduct comparative genomic analyses across fission yeast species.

The paper shows that caffeine induces epigenetic resistance in fission yeast through heterochromatin silencing, which can lead to cross-resistance to fungicides.

The paper identifies Hap2-Ino80's role in promoting de novo CENP-A chromatin assembly by facilitating transcription and H3 turnover at centromeres.

The paper shows that centromere DNA from non-homologous fission yeast species can be recognized and function across species, despite lacking sequence conservation.

The paper uses transposon mutagenesis and a hidden Markov model to identify functional elements in the fission yeast genome, finding that 90% of the genome has fitness consequences.

The paper shows centromeric DNA drives H3 nucleosome turnover and CENP-A deposition during the cell cycle in fission yeast.