Robin C. Allshire

This study identifies transient heterochromatin islands in Cryptococcus neoformans that contribute to fluconazole heteroresistance, distinct from aneuploidy.

The paper uses synthetic TALE proteins to identify chromatin-associated proteins on repetitive elements in Trypanosoma brucei, revealing their roles in chromosome structure and function.

The paper shows that heterochromatin epimutations in fission yeast cause mitochondrial dysfunction and antifungal resistance by repressing genes involved in mitochondrial function.

The paper identifies the SPARC complex in Trypanosoma brucei, showing it defines RNAPII promoters and regulates transcription start site positioning and directionality.

The paper identifies chromatin factors in Trypanosoma brucei and their association with transcription initiation and termination sites through proteomic and ChIP-seq analyses.

The paper shows that caffeine induces epigenetic resistance in fission yeast through heterochromatin silencing, which can lead to cross-resistance to fungicides.

The paper identifies Hap2-Ino80's role in promoting de novo CENP-A chromatin assembly by facilitating transcription and H3 turnover at centromeres.

The paper shows that centromere DNA from non-homologous fission yeast species can be recognized and function across species, despite lacking sequence conservation.

The paper uses transposon mutagenesis and a hidden Markov model to identify functional elements in the fission yeast genome, finding that 90% of the genome has fitness consequences.

The paper identifies H2A.ZPht1 and Swr1 as essential for de novo CENP-A/Cnp1 assembly at centromeres in fission yeast.

The paper shows centromeric DNA drives H3 nucleosome turnover and CENP-A deposition during the cell cycle in fission yeast.