Pin Tong

Variable ectopic heterochromatin islands provide an alternative route to antifungal heteroresistance in Cryptococcus neoformans

This study identifies transient heterochromatin islands in Cryptococcus neoformans that contribute to fluconazole heteroresistance, distinct from aneuploidy.

Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

The paper uses synthetic TALE proteins to identify chromatin-associated proteins on repetitive elements in Trypanosoma brucei, revealing their roles in chromosome structure and function.

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance

The paper shows that heterochromatin epimutations in fission yeast cause mitochondrial dysfunction and antifungal resistance by repressing genes involved in mitochondrial function.

A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination

The paper identifies chromatin factors in Trypanosoma brucei and their association with transcription initiation and termination sites through proteomic and ChIP-seq analyses.

Hap2-Ino80 facilitated transcription promotes de novo establishment of CENP-A chromatin

The paper identifies Hap2-Ino80's role in promoting de novo CENP-A chromatin assembly by facilitating transcription and H3 turnover at centromeres.

Inter-species conservation of organisation and function between non-homologous regional centromeres

The paper shows that centromere DNA from non-homologous fission yeast species can be recognized and function across species, despite lacking sequence conservation.

Fitness Landscape of the Fission Yeast Genome

The paper uses transposon mutagenesis and a hidden Markov model to identify functional elements in the fission yeast genome, finding that 90% of the genome has fitness consequences.