Jan Kosiński

The paper identifies and characterizes a non-canonical bacterial protein translocation-folding complex using cryo-electron tomography, proteomics, and structure prediction in Mycoplasma pneumoniae.

The paper maps virus-host protein contact sites during influenza A virus infection, revealing new interactions and paraspeckle disassembly as a novel infection mechanism.

This paper introduces rejection sampling to improve macromolecular complex detection in cryo-electron tomography by incorporating biological constraints, achieving performance comparable to deep learning methods without annotated data.

The paper introduces HMFF, a method integrating experimental data into membrane simulations, and applies it to various biological systems to enable multi-scale modeling.

AlphaPulldown2 provides a pipeline for high-throughput protein structural modeling with automated workflows and improved data management.

This study improves AlphaFold 3 by integrating crosslink data as covalently-bound ligands, enhancing model accuracy for complexes with limited evolutionary data.

ColabSeg is a tool for processing and visualizing membrane segmentations from cryo-ET data, enabling high-throughput segmentation and training of CNNs.

The paper introduces pyTME, a Python library for template matching in cryo-EM data that improves efficiency and scalability for large datasets.

This study identifies potential antiviral drugs against influenza virus by computationally prioritizing drug-target pairs and validating their activity in cell lines.

AlphaPulldown is a Python package that simplifies protein-protein interaction screens and high-throughput modelling using AlphaFold-Multimer, offering a CLI, confidence scores, and a graphical tool.

The paper uses AI to create a dynamic model of the human nuclear pore complex, showing how the protein scaffold interacts with the nuclear envelope.

The paper introduces Assembline, a software package for integrative structural modelling of macromolecular complexes, enabling efficient sampling and analysis of conformational space.