Author

Sang Hyun Lee

Korea Advanced Institute of Science and TechnologyORCID 0009-0009-3323-7905Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ellen Y. ZhangiD· 2 shared Inkyung JungiD· 2 shared Jaeun Jung· 2 shared Su‐Jin HeoiD· 2 shared Bat‐Ider TumenbayariD· 1 shared Claudia LoebeliD· 1 shared D K KimiD· 1 shared Douglas W. RobertsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBioengineering

Ellen Y. ZhangORCID

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2 papers

Recent·Most cited

BioengineeringJournal of Bone and Mineral ResearchPeer-reviewedJun 5, 2026

Hyperactive BMP and Mechanosignaling Remodel Chromatin to Drive Aberrant Osteogenesis in FOP

Ellen Y. Zhang, Douglas W. Roberts, Sang Hyun Lee…·Su‐Jin Heo

This study shows that the Acvr1R206H mutation in FOP remodels chromatin through BMP-SMAD and Rho/ROCK signaling, driving aberrant osteogenesis, and identifies reversible chromatin changes as a therapeutic target.

DOI 10.1093/jbmr/zjag089

mouseATAC-seq

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BioengineeringbioRxivPreprintMay 13, 2026

Reprogramming Dedifferentiation Regulatory Networks Preserves Human Chondrocyte Phenotypes

Ellen Y. Zhang, Sang Hyun Lee, Yu‐Chung Liu…·Su‐Jin Heo

This study identifies chromatin stability as critical for preserving chondrocyte function during expansion and shows that Fludarabine maintains phenotype by stabilizing chromatin and reducing STAT1 activity.

DOI 10.64898/2026.05.10.724134

humanscRNA-seq

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