Author

Keara Monaghan

University of PennsylvaniaORCID 0009-0009-4977-3200Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Christopher J. LengneriD· 2 shared Kayla Durning· 2 shared Devon Bankler-Jukes· 1 shared JH Rhoades· 1 shared M. Andres Blanco· 1 shared María F. Carrera RodrígueziD· 1 shared Mario Andres BlancoiD· 1 shared Melissa S. Kim· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Christopher J. LengnerORCID

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2 papers

Recent·Most cited

Cancer BiologyCell ReportsPeer-reviewedMar 1, 2026

APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

Zvi Cramer, Keara Monaghan, Ricardo Petroni…·Christopher J. Lengner

This study identifies SETD8 as a target of APC-coordinated GSK3 phosphorylation in colorectal cancer, showing that phosphorylation suppresses SETD8's oncogenic activity.

DOI 10.1016/j.celrep.2026.117045

mouseproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 6, 2025

APC loss promotes intestinal transformation through induction of bistable stem cell states

N Li, RL Myers, Qin Zhu…·Christopher J. Lengner

This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky