Author

Kayla Durning

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Christopher J. LengneriD· 2 shared Keara MonaghaniD· 2 shared Devon Bankler-Jukes· 1 shared JH Rhoades· 1 shared M. Andres Blanco· 1 shared María F. Carrera RodrígueziD· 1 shared Mario Andres BlancoiD· 1 shared Melissa S. Kim· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Christopher J. LengnerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

Zvi Cramer, Keara Monaghan, Ricardo Petroni, Xin Wang, Stephanie Adams-Tzivelekidis, Kayla Durning, Melissa S. Kim, Yuhua Tian, Nicolette M. Johnson, María F. Carrera Rodríguez, Xiaoyuan Gao, Nicolae Adrian Leu, Simone Sidoli, Ning O. Li, M. Andres Blanco, Christopher J. Lengner

This study identifies SETD8 as a target of APC-coordinated GSK3 phosphorylation in colorectal cancer, showing that phosphorylation suppresses SETD8's oncogenic activity.

Cell Reports · Mar 1, 2026Peer-reviewedCancer Biology

APC loss promotes intestinal transformation through induction of bistable stem cell states

N Li, RL Myers, Qin Zhu, Ye Tian, Kayla Durning, X Wang, NA Leu, JH Rhoades, Devon Bankler-Jukes, Keara Monaghan, Stephanie Adams‐Tzivelekidis, Oz Pomp, Oscar Pellón-Cárdenas, Mario Andres Blanco, Michael Paul Verzi, , Christopher J. Lengner

This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.

bioRxiv · Mar 6, 2025 · PreprintCancer Biology