Author

Silvia Toledo Ramos

University of MinnesotaORCID 0009-0009-5049-4145Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Erandika SenevirathneiD· 2 shared Tanya S. FreedmaniD· 2 shared Carter SellneriD· 1 shared Myra G. NuneziD· 1 shared Richard T. CattleyiD· 1 shared Whitney L. SwansoniD· 1 shared William F. HawseiD· 1 shared William K. KanagyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

S. Erandika SenevirathneORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintFeb 27, 2026

Dose-dependent activation of Syk and SHIP1 by LynA and LynB at steady state creates a threshold for macrophage signaling in the absence of receptor engagement

S. Erandika Senevirathne, Carter Sellner, Silvia Toledo Ramos, Tanya S. Freedman

The paper shows that LynA and LynB expression levels determine steady-state phosphorylation of Syk and SHIP1, limiting macrophage signaling without microbial stimulation.

DOI 10.64898/2026.02.25.708040

mouseexperimental assay

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ImmunologybioRxivPreprintApr 16, 2025

Steady-state phosphorylation of SHIP1 by Lyn restricts macrophage activation in the absence of a phagocytic synapse

S. Erandika Senevirathne, William K. Kanagy, Richard T. Cattley…·Tanya S. Freedman

The paper shows that Lyn maintains steady-state phosphorylation of SHIP1, balancing Erk and Akt signaling in macrophages, and that phagocytic synapse formation bypasses this requirement.

1 citation

mouseproteomics

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