Author
University of CambridgeORCID 0009-0009-5070-0156Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Pritchard, Thomas, M.A., Rohit Gupta, James P. Higham…·David Colin Bulmer
This study shows that inhibiting TYK2 reduces IL-6 and OSM-induced calcium signaling in murine sensory neurons, suggesting therapeutic potential for pain management in IBD.
James P. Higham, Luke W Paine, Alanna M. Cameron…·David Colin Bulmer
The paper investigates how cromolyn, a GPR35 agonist, inhibits PGE2-induced TRPV1 sensitization in sensory neurons, supporting GPR35 as an anti-nociceptive target.
Luke W Paine, Rohit Gupta, James P. Higham…·David Colin Bulmer
This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.
Luke W Paine, James P. Higham, Katie H. Barker…·David Colin Bulmer
The paper identifies IL-17's role in enhancing pain sensitivity in the gut via PI3K-dependent mechanisms in ulcerative colitis.