Luke W Paine

The paper investigates how cromolyn, a GPR35 agonist, inhibits PGE2-induced TRPV1 sensitization in sensory neurons, supporting GPR35 as an anti-nociceptive target.

This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.

The paper investigates the role of mast cells in modulating hippocampal synaptic transmission at the hippocampal-thalamic border during early brain development in mice.

This paper develops a strategy to reduce immunotoxicity in self-amplifying RNA by encoding immune suppressors that bypass translation shutdown, enabling sustained transgene expression in mouse cells.

The paper identifies IL-17's role in enhancing pain sensitivity in the gut via PI3K-dependent mechanisms in ulcerative colitis.

This study shows TRPV4 activation in the colon increases afferent activity via mucosal release of ATP and glutamate, suggesting a target for visceral pain treatment.

This study investigates how inflammatory mediators affect TRPM3 channel function in mouse sensory neurons and finds that IL-1β and TNF potentiate TRPM3 without changing its expression, while pharmacological blockade does not alleviate inflammatory pain in a specific model.

This study correlates mouse digging behavior with human pain experience, showing that digging deficits reflect pain levels and that meloxicam is more effective than gabapentin in alleviating these deficits.