Bharath Saravanan

The paper constructs an integrative single-cell epigenomic atlas of the adult mouse brain, mapping chromatin states and gene regulatory programs across 100 cell subclasses.

This study uses single-molecule spatial genomics to show how extrachromosomal DNA is organized and regulated in glioblastoma, linking it to tumor heterogeneity and microenvironmental influences.

The paper investigates how chromatin architecture, mediated by histone modifiers and loop-extrusion machinery, influences gene regulation in mouse embryonic stem cells under different conditions.

This study shows that RNA binding enhances estrogen receptor-alpha (ER) chromatin binding, which limits its transcriptional activation in response to estrogen.

The paper shows boundary-associated RNAs enhance TAD insulation by promoting CTCF clustering at TAD boundaries.

The paper shows that unliganded ERα pre-marks enhancer sites, which form 3D clusters upon ligand exposure, driving transient gene expression.