Marie Emilie Maeland

This paper introduces Mespilia globulus as a new sea urchin model with rapid development and tractability for genomic and developmental studies, showing a conservative gene repertoire and no heteromorphic sex chromosomes.

The paper identifies neuronal vulnerability to C9orf72 repeat expansion by analyzing transcriptional states in a Drosophila model, finding that Xbp1 expression correlates with resistance to toxicity.

This study shows that increasing pyruvate import in neurons rescues dementia-like phenotypes in fly models by clearing toxic protein deposits.