Author

Dongwei Xu

University College LondonORCID 0000-0001-9802-0664Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 3 Approach:statistical model· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adrian M. IsaacsiD· 3 shared Sharifah AnoariD· 3 shared Teresa NiccoliiD· 3 shared Alec J. VincentiD· 2 shared Benjamin Aleyakpo· 2 shared Dunxin SheniD· 2 shared Elli Tsintzas· 2 shared Marie Emilie MaelandiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Adrian M. IsaacsORCID

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3 papers

Recent·Most cited

Metformin promotes broad neuroprotection and proteostatic resilience via rngo/DDI2 stabilisation

Dongwei Xu, Youngah Kim, Sharifah Anoar, Xinwa Jiang, Argyro Alatza, Riccardo Zenezini Chiozzi, Konstantinos Thalassinos, Adrian M. Isaacs, Tammaryn Lashley, Selina Wray, Teresa Niccoli

This paper shows metformin protects neurons by stabilizing rngo/DDI2, enhancing proteostasis and reducing toxicity in multiple neurodegenerative models.

bioRxiv · Feb 13, 2026 · PreprintNeuroscience

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1 transcription signature

Dunxin Shen, Alec J. Vincent, Evan Udine, Yazead Buhidma, Sharifah Anoar, Elli Tsintzas, Marie Emilie Maeland, Dongwei Xu, Mireia Carcolé, David Osumi-Sutherland, Benjamin Aleyakpo, Alexander J. Hull, Guillermo Martínez-Corrales, Nathaniel S. Woodling, Rosa Rademakers, , Teresa Niccoli

The paper identifies neuronal vulnerability to C9orf72 repeat expansion by analyzing transcriptional states in a Drosophila model, finding that Xbp1 expression correlates with resistance to toxicity.

Cell Reports · Apr 1, 2025Peer-reviewedNeuroscience

A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models

Dongwei Xu, Alec J. Vincent, Andrés González‐Gutiérrez, Benjamin Aleyakpo, Sharifah Anoar, Ashling Giblin, Magda Luciana Atilano, Mirjam Lisette Adams, Dunxin Shen, Annora Thoeng, Elli Tsintzas, Marie Emilie Maeland, Adrian M. Isaacs, Jimena A. Sierralta, Teresa Niccoli

This study shows that increasing pyruvate import in neurons rescues dementia-like phenotypes in fly models by clearing toxic protein deposits.

PLoS Genetics · Sep 21, 2023Peer-reviewedNeuroscience