Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate

Anna J. Jasinska; Ivette Zelaya; Susan K. Service; Christine B. Peterson; Rita M. Cantor; Oi‐Wa Choi; Joseph A. DeYoung; Eleazar Eskin; Lynn A. Fairbanks; Scott C. Fears; Allison Furterer; Yu Shu Huang; Vasily E. Ramensky; Christopher A. Schmitt; Hannes Svardal; Matthew J. Jorgensen; Jay R. Kaplan; Diego Villar; Bronwen L. Aken; Paul Flicek; Rishi Nag; Emily S. W. Wong; John Blangero; Thomas D. Dyer; Marina Bogomolov; Yoav Benjamini; George M. Weinstock; Ken Dewar; Chiara Sabatti; Richard K. Wilson

doi:10.1038/ng.3959

GeneticsNature GeneticsOct 30, 2017

Peer-reviewed journal article

Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate

Anna J. Jasinska iD, Ivette Zelaya, Susan K. Service iD, Christine B. Peterson iD, Rita M. Cantor iD, Oi‐Wa Choi, Joseph A. DeYoung, Eleazar Eskin iD, Lynn A. Fairbanks, Scott C. Fears iD, Allison Furterer, Yu Shu Huang iD, Vasily E. Ramensky iD, Christopher A. Schmitt iD, Hannes Svardal iD, Matthew J. Jorgensen iD, Jay R. Kaplan iD, Diego Villar iD, Bronwen L. Aken iD, Paul Flicek iD, Rishi Nag iD, Emily S. W. Wong iD, John Blangero iD, Thomas D. Dyer iD, Marina Bogomolov iD, , Nelson B. Freimer iD

Abstract

By analyzing multi-tissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalogue of expression quantitative trait loci (eQTLs) in a non-human primate model. This catalogue contains more genome-wide significant eQTLs, per sample, than comparable human resources, and reveals sex and age-related expression patterns. Findings include a master regulatory locus that likely plays a role in immune function, and a locus regulating hippocampal long non-coding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.

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