Sirisha Pochareddy

Human-specific features of the cerebellum and ZP2-regulated synapse development

The paper identifies human-specific transcriptomic and regulatory features in the cerebellum, including ZP2's role in synapse development and regulation.

Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons

The paper identifies mammalian-specific gene regulatory elements and their role in neocortical neuron subtype diversity and connectivity, linking them to neurodevelopmental disorders.

Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse neocortex

The paper quantifies developmental changes in voltage-gated sodium channel exon expression in human and mouse neocortex, identifying key splicing transitions associated with neurological disorders.

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

The paper introduces a machine learning method to detect somatic L1 insertions in human brain tissue, revealing their widespread distribution in neurons and glia and potential role in neuropsychiatric diseases.

Neuronal and glial 3D chromatin architecture illustrates cellular etiology of brain disorders

The paper integrates chromatin architecture with transcriptomic data to explore cell-type-specific gene regulatory networks in brain disorders, identifying distinct cellular contributions to Alzheimer's and psychiatric diseases.

Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex

The paper uses whole-genome and RNA sequencing from the human prefrontal cortex to identify genetic variants and transcriptomic changes associated with neurodevelopment and neuropsychiatric disorders.

Limited contribution of rare, noncoding variation to autism spectrum disorder from sequencing of 2,076 genomes in quartet families

This study examines the role of noncoding variation in autism spectrum disorder using whole genome sequencing of 2,076 genomes, finding no significant association after correction for multiple testing.