Author

Angela L. Elwell

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Dan LiangiD· 2 shared Daniel H. GeschwindiD· 2 shared Jason L. SteiniD· 2 shared Kenan P. Courtney· 2 shared Kerry E. Cheek· 2 shared Luis de la Torre-UbietaiD· 2 shared Michael I. LoveiD· 2 shared Michael J. LaffertyiD· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Dan LiangORCID

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Author profile →

3 papers

Recent·Most cited

Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiation

Dan Liang, Angela L. Elwell, Nil Aygün, Oleh Krupa, Justin M. Wolter, Felix A. Kyere, Michael J. Lafferty, Kerry E. Cheek, Kenan P. Courtney, Marianna Yusupova, Melanie E. Garrett, Allison E. Ashley‐Koch, Gregory E. Crawford, Michael I. Love, Luis de la Torre-Ubieta, , Jason L. Stein

The paper identifies cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiation and links these to regulatory mechanisms of neuropsychiatric disorder risk variants.

Nature Neuroscience · May 20, 2021Peer-reviewedGenetics

Genetic effects on brain traits impact cell-type specific gene regulation during neurogenesis

Nil Aygün, Angela L. Elwell, Dan Liang, Michael J. Lafferty, Kerry E. Cheek, Kenan P. Courtney, Jessica T. Mory, Ellie Hadden-Ford, Oleh Krupa, Luis de la Torre-Ubieta, Daniel H. Geschwind, Michael I. Love, Jason L. Stein

The paper identifies cell-type specific regulatory mechanisms in human neural progenitors and their neuronal progeny that influence brain-relevant traits, revealing loci not detected in bulk tissue.

bioRxiv · Oct 21, 2020 · PreprintGenetics

Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis

Morten Seirup, Li‐Fang Chu, Srikumar Sengupta, Ning Leng, Hadley Browder, Kevin Kapadia, Christina M. Shafer, Bret M. Duffin, Angela L. Elwell, Jennifer M. Bolin, Scott Allen Swanson, Ron M. Stewart, Christina M. Kendziorski, James Alexander Thomson, Rhonda L. Bacher

This study evaluates the reproducibility of spatial ordering analysis across different single-cell RNA-seq protocols, finding high reproducibility despite differences in sequencing depth and computational methods.

PLoS ONE · Sep 28, 2020Peer-reviewedGenomics