Journal of Biological ChemistryPharmacology & ToxicologyPeer-reviewed journal article
Praziquantel activates a schistosome transient receptor potential channel
S. K. Park, P. McCusker, P. I. Dosa, J. D. Chan, J. S. Marchant
Abstract
The anthelmintic drug praziquantel (PZQ) is used to treat schistosomiasis, a neglected tropical disease that affects over 200 million people. The target of PZQ in the blood fluke responsible for this disease is unknown. Here, we demonstrate that PZQ activates a transient receptor potential (TRP) channel found in parasitic schistosomes and other PZQ-sensitive parasites.
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