Author

P. McCusker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. D. Chan· 4 shared J. M. Cook· 2 shared A. Y. Fedorov· 1 shared B. C. Smith· 1 shared C. M. Rohr· 1 shared D. Sharmin· 1 shared F. Rashid· 1 shared G. Li· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersPharmacology & Toxicology

J. D. Chan

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4 papers

Recent·Most cited

Development of non-sedating antischistosomal benzodiazepines

M. Y. Mian, D. Sharmin, P. Mondal, J. B. Belayet, M. M. Hossain, P. McCusker, K. T. Ryan, A. Y. Fedorov, H. A. Green, S. S. Ericksen, M. Zamanian, V. V. N. Phani Babu Tiruveedhula, J. M. Cook, J. D. Chan

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.

bioRxiv · Jan 26, 2024 · PreprintPharmacology & Toxicology

Schistosomes alter expression of immunomodulatory gene products following in vivo praziquantel exposure

P. McCusker, C. M. Rohr, J. D. Chan

This study investigates how praziquantel exposure affects Schistosoma mansoni gene expression in vivo, revealing up-regulation of immunomodulatory and anticoagulant gene products.

bioRxiv · Jan 22, 2020 · PreprintPharmacology & Toxicology

Praziquantel activates a schistosome transient receptor potential channel

S. K. Park, P. McCusker, P. I. Dosa, J. D. Chan, J. S. Marchant

This study identifies a transient receptor potential channel as the target of praziquantel in schistosomes and other PZQ-sensitive parasites.

Journal of Biological Chemistry · Dec 1, 2019Peer-reviewedPharmacology & Toxicology

Non-sedating benzodiazepines cause contractile paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni

P. McCusker, Y. Mian, G. Li, M. D. Olp, V. V. N. P. B. Tiruveedhula, F. Rashid, L. K. Golani, B. C. Smith, J. M. Cook, J. D. Chan

This study identifies non-sedating benzodiazepines that cause contractile paralysis and tissue damage in Schistosoma mansoni, offering potential for new anti-schistosomal drugs with reduced host side effects.

bioRxiv · Jul 8, 2019Pharmacology & Toxicology