bioRxivMicrobiology
Co-infection of influenza A virus enhances SARS-CoV-2 infectivity
L. Bai, Y. Zhao, J. Dong, S. Liang, M. Guo, X. Liu, X. Wang, Z. Huang, X. Sun, Z. Zhang, L. Dong, Q. Liu, Y. Zheng, D. Niu, M. Xiang, K. Song, J. Ye, W. Zheng, Z. Tang, M. Tang, Y. Zhou, C. Shen, M. Dai, L. Zhou, Y. Chen, , K. Xu
Abstract
The upcoming flu season in the northern hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental co-infection of IAV with either pseudotyped or SARS-CoV-2 live virus, we found that IAV pre-infection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice co-infected with IAV in vivo. Moreover, such enhancement of SARS-CoV-2 infectivity was not seen with several other viruses probably due to a unique IAV segment as an inducer to elevate ACE2 expression. This study illustrates that IAV has a special nature to aggravate SARS-CoV-2 infection, and prevention of IAV is of great significance during the COVID-19 pandemic.
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