M. Guan

Neu5Gc binding loss of subtype H7 influenza A virus facilitates adaptation to gallinaceous poultry following transmission from waterbirds but restricts spillback

This study shows H7 influenza A viruses lose Neu5Gc binding during adaptation to chickens, enhancing transmissibility in poultry but reducing transmission back to wild birds.

Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy

This study shows EHMT1 and EHMT2 have distinct roles in cancer therapy, with EHMT1 affecting DNA replication and alkylating agents, while EHMT2 influences immunotherapy response via STING expression.

Biodegradable hyperbranched poly(amine-co-ester)-based polymeric nanoparticles for mRNA delivery

This study develops a biodegradable hyperbranched poly(amine-co-ester) nanoparticle for efficient and safe mRNA delivery, showing improved performance over existing commercial reagents.

Grand Biological Universe: Genome space geometry unravels looking for a single metric is likely to be futile in evolution

This study explores genome space geometry across seven kingdoms, showing that a single metric cannot accurately measure differences between biological universes due to space-time distortion.

Determinants of Disordered Protein Co-Assembly Into Discrete Condensed Phases

The paper identifies sequence determinants of IDR co-assembly into distinct condensed phases and reveals physicochemical principles governing phase separation specificity.

Open-3DSIM: an Open-source three-dimensional structured illumination microscopy reconstruction platform

Open-3DSIM improves lateral and axial resolution in 3D structured illumination microscopy and offers artifact suppression and defocus elimination across various specimens.

SARS-CoV-2 exposure in Norway rats (Rattus norvegicus) from New York City

The paper tests SARS-CoV-2 exposure in NYC rats, finding 16.5% seropositive and partial genomes in some, and shows rat susceptibility to Alpha, Delta, and Omicron variants.

Time dependent proinflammatory responses shape virus interference during coinfections of influenza A virus and influenza D virus

This study shows that influenza A and D viruses interfere with each other during coinfection based on the timing and order of infection, with proinflammatory responses playing a key role.

A LAMP-based microfluidic chip for rapid detection of pathogen in Cryptococcal meningitis

This paper develops a LAMP-based microfluidic chip for rapid, portable detection of Cryptococcus in CM, enabling visual, sample-to-answer diagnosis without additional instruments.

Tissue tropisms of avian influenza A viruses affect their spillovers from wild birds to pigs

This study identifies that avian influenza A viruses with specific tissue tropisms in swine upper respiratory tracts can spill over to pigs, increasing the risk of viral adaptation and reassortment.