Transform the Information Landscape: Applying Waddington Landscape to Information Theory of Aging and Epigenetic Rejeuvanation

The Information Theory of Aging (ITOA) provides a framework for understanding aging and rejuvenation via changes in epigenetic information. These changes are visualized using Waddington landscape -- a 3D topology that represents cell trajectories during changes in cell identity -- constructed from field decomposition of scRNA velocity data. Studies have demonstrated that the Waddington landscape can serve as a mechanistic model of epigenetic information. It explains how age-driven decline in cellular function and reprogramming-induced rejuvenation can be understood by studying the transformations in the Waddington landscape. This study provides insights into the representation of epigenetic information and discusses how it can be reprogrammed to restore a younger cellular state.