Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in mice
Nathaniel D. Jackson, Fuchun Zhou, Anastasija Čupić, Tolga Çağatay, Haiping Hao, Vinay Shivanna, Ruby A. Escobedo, Kevin Chiem, Chengjin Ye, Lisa Miorin, Beatriz M. A. Fontoura, Adolfo García‐Sastre, Alexander A. Bukreyev, Luis Martínez‐Sobrido
This study identifies critical residues in SARS-CoV-2 Nsp1 that determine viral pathogenicity in mice by reducing replication and immune response severity.
bioRxiv · Aug 19, 2026 · PreprintMicrobiology