Author

C. E. Karl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 1 Assay:flow cytometry· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

M. S. Diamond· 4 shared D. K. Edwards· 3 shared B. Ying· 2 shared C.-Y. Liang· 2 shared L. B. Thackray· 2 shared P. Desai· 2 shared A. C. Santana· 1 shared A. Carfi· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersMicrobiology

M. S. Diamond

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2

P. Desai, C. E. Karl, B. Ying, C.-Y. Liang, T. Garcia-Salum, A. C. Santana, F. T. Caten, J. F. Urban, S. M. Elbashir, D. K. Edwards, S. P. Ribeiro, L. B. Thackray, R.-P. K. Sekaly, M. S. Diamond

This study shows that intestinal helminth infection reduces T cell responses to an mRNA SARS-CoV-2 vaccine and weakens protection against Omicron but not the ancestral strain.

bioRxiv · Jan 14, 2024 · PreprintImmunology

Fc-gamma receptor-dependent antibody effector functions are required for vaccine protection against infection by antigenic variants of SARS-CoV-2

S. R. Mackin, P. Desai, B. M. Whitener, C. E. Karl, M. Liu, R. S. Baric, D. K. Edwards, T. M. Chicz, R. P. McNamara, G. Alter, M. S. Diamond

This study shows that Fc-gamma receptor-dependent antibody effector functions are necessary for vaccine protection against antigenic variants of SARS-CoV-2, including Omicron.

bioRxiv · Nov 27, 2022 · PreprintMicrobiology

Nasally-delivered interferon-{lambda} protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron

Z. Chong, C. E. Karl, P. J. Halfmann, Y. Kawaoka, E. S. Winkler, J. Yu, M. S. Diamond

This study shows that nasal delivery of IFN-λ protects mice against SARS-CoV-2 variants including Omicron in both upper and lower respiratory tracts without causing excessive inflammation.

bioRxiv · Jan 21, 2022 · PreprintMicrobiology

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

B. Ying, B. Whitener, L. A. VanBlargan, A. O. Hassan, S. Shrihari, C.-Y. Liang, C. E. Karl, S. Mackin, R. E. Chen, N. M. Kafai, S. H. Wilks, D. J. Smith, J. M. Carreno, G. Singh, F. Krammer, , M. S. Diamond

This study evaluates the protective efficacy of mRNA vaccines against SARS-CoV-2 variants in mice, showing that low-dose vaccines lead to breakthrough infections with Delta variant.

bioRxiv · Aug 25, 2021Microbiology