Author

A. C. Sims

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. S. Baric· 3 shared H. D. Mitchell· 2 shared K. M. Waters· 2 shared S. R. Leist· 2 shared A. J. Brown· 1 shared A. J. Eisfeld· 1 shared A. Kolykhalov· 1 shared A. Pruijssers· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

R. S. Baric

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Host network-based discovery of critical regulators of innate immunity, virus growth, and pathogenesis in influenza virus infection

A. J. Eisfeld, S. Fan, H. Rao, B. A. Venkatachalam, D. W. Smith, P. J. Halfmann, K. B. Walters, S. Nair, L. B. Thackray, J. F. Kocher, A. C. Sims, H. D. Mitchell, G. Neumann, V. Blank, K. M. Waters, , Y. Kawaoka

The paper identifies novel innate immune regulators affecting influenza virus replication and pathogenesis through experimental validation of network model predictions.

bioRxiv · Aug 29, 2022 · PreprintMicrobiology

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

T. P. Sheahan, A. C. Sims, S. Zhou, C. Hill, S. R. Leist, A. Schaefer, M. Agostini, A. Pruijssers, A. J. Brown, G. Bluemling, M. Natchus, M. Saindane, A. Kolykhalov, G. Painter, R. Swanstrom, , R. S. Baric

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.

bioRxiv · Mar 19, 2020 · PreprintMicrobiology

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

V. D. Menachery, L. E. Gralinski, H. D. Mitchell, K. H. Dinnon, S. R. Leist, B. L. Yount, R. L. Graham, E. T. McAnarney, K. G. Stratton, A. S. Cockrell, K. Debbink, A. C. Sims, K. M. Waters, R. S. Baric

This study shows that disrupting MERS-CoV NSP16's 2O methyl-transferase activity attenuates viral pathogenesis and provides a live attenuated vaccine platform.

bioRxiv · Aug 8, 2017Microbiology