Attenuation of Hyperalgesia and Allodynia by some Phenolic Acids in Paclitaxel Induced Neuropathy

Abstract

Paclitaxel, an anticancer drug induced neuropathy is widely used animal model to evaluate new drugs in neuropathy. As oxidative stress is key contributor in pathogenesis of neuropathy, many phenolic acids with antioxidant potential are proven as neuroprotective. So,present work undertaken to evaluate effect of syringic acid and sinapic acid in paclitaxel induced neuropathy. We evaluated effect on mechanical and thermal hyperalgesia and allodynia which are vital signs of neuropathy. 4 weeks treatment by different doses of syringic acid and sinapic acid shown significant protective effect on hyperalgesia and allodynia in dose dependant manner assessed by Randello Selitto, hot plate, cold plate and Von Frey filament test. As these phenolic acids attenuates hyperalgesia and allodynia in neuropathy, can be therapeutically used in combination with current treatment of neuropathy. Summary statementHyperlagesia and allodynia are major signs of neuropathy and this article focus on reduction of hyperalgesia and allodynia by syringic and sinapic acid in neuropathy induced by paclitaxel.