Ayesha Ahmad

This study shows that PAR2 in sensory neurons contributes to paclitaxel-induced pain and neuropathy in mice, and that targeting PAR2 can alleviate these symptoms.

This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.

The paper develops a PAR3 agonist and shows it induces mechanical hypersensitivity in mice, suggesting PAR3's role in nociception and plasticity.

This study identifies a specific subset of sensory neurons expressing PAR2 that mediate mechanical and affective pain behaviors, clarifying the cellular basis of PAR2-evoked pain.

The paper compares transcriptomes of native and cultured human and mouse dorsal root ganglia, finding reduced neuronal gene expression in culture but presence of key pharmacological targets.

The paper identifies the RagA-mTORC1 network as a key driver of neuropathic pain through cell-specific translational profiling in nociceptors.