henhao
Sign in
MicrobiologyThe Lancet Infectious Diseases
Peer-reviewed journal article

Antiviral activity of Tecovirimat against Mpox virus clades 1a, 1b, 2a and 2b

Jeanne PostaliD, Florence Guivel‐BenhassineiD, Françoise PorrotiD, Quentin Grassin, Jack M. CrookiD, Riccardo VernuccioiD, Valérie CaroiD, Jessica VanhomwegeniD, Pablo Guardado‐CalvoiD, Etienne Simon‐LorièreiD, Laurent DacheuxiD, Jean‐Claude ManuguerraiD, Olivier SchwartziD

PDFDOIPreprint
Post to X
Threads on XPost to BlueskyThreads on Bluesky

Abstract

The recent Mpox virus (MPXV) outbreak was caused by a novel and more pathogenic clade 1b virus. We compared the antiviral efficacy of Tecovirimat in cell culture, against the two ancestral clades 1a and 2a, the clade 2b that circulated in 2022, and the recent clade 1b virus. We report that Tecovirimat similarly inhibits the replication of all four MPXV clades, at nanomolar concentrations (nM). Our results suggest that Tecovirimat remains a therapeutic option against the latest clade 1b virus.

02 /Specification & Classification

Click any tag to browse matching papers
Citations
22
FWCI
10.05
Field percentile
top 1%
OpenAlex Topics

Reproducibility ledger

Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.

Sign in to file a reproducibility report.

Related papers

Similarity Map
SelectedSame fieldCross-field
THISHorton '25Frenois-Vey '22Jeyachandra '25Bojkova '22Akazawa '22Chiem '23
82% semantic matchMicrobiology
Amanda Horton, Helen Berryman, Yasmin M. Surani+4 more·bioRxiv·Jan 11, 2025· 2 citations