A. Nogales

Antivirals against monkeypox infections

This study evaluates 19 compounds for antiviral activity against Orthopoxviruses, identifying 13 with activity against vaccinia virus and 11 with activity against monkeypox virus.

Vaccinia virus attenuation by codon deoptimization of the A24R gene for vaccine development

This study attenuates vaccinia virus by codon deoptimization of the A24R gene, creating a safe and protective vaccine candidate against poxvirus infection.

A single amino acid substitution in PB1 of pandemic H1N1 with A/Ann Arbor/6/60 master donor virus mutations as a novel live-attenuated influenza virus vaccine

This paper shows that a single amino acid change in the PB1 protein of the pandemic H1N1 virus can create a live-attenuated vaccine with reduced pathogenicity and transmission.

Bi-reporter vaccinia virus for tracking viral infections in vitro and in vivo

This paper introduces bi-reporter vaccinia viruses expressing both fluorescent and luciferase genes to track viral infections in vitro and in vivo, enabling detailed study of infection dynamics and host-pathogen interactions.

Amino acid residues involved in inhibition of host gene expression by influenza A/Brevig Mission/1/1918 PA-X

The paper identifies amino acid residues critical for PA-X's host gene expression inhibition using a bacteria-based system.

A broad and potent H1-specific human monoclonal antibody produced in plants prevents influenza virus infection and transmission in guinea pigs

This paper produces a human monoclonal antibody against H1N1 influenza in plants and shows it prevents infection and transmission in guinea pigs, similar to mammalian-produced versions.

Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation

This study analyzes influenza A virus evolution in mice during serial passage, finding varied mutation patterns and no clear adaptive evolution or sialic acid-related sequence differences.