Developmental olfactory dysfunction and abnormal odor memory in immune-challenged Disc1+/- mice

Neuronal activity in the olfactory bulb (OB) drives coordinated activity in the hippocampal-prefrontal network during early development. Inhibiting OB output in neonatal mice disrupts functional development of the hippocampal formation as well as cognitive abilities. These impairments manifest early in life and resemble dysfunctions of the hippocampus and the prefrontal cortex that have been linked to neuropsychiatric disorders. Thus, we investigated a disease mouse model and asked whether activity in the OB might be altered, thereby contributing to the dysfunctional development of the hippocampal-prefrontal network. We addressed this question by combining in vivo electrophysiology with behavioral assessment of immune-challenged Disc1+/-mice that mimic the dual genetic-environmental etiology of neuropsychiatric disorders. In wildtype mice, we found high DISC1 expression levels in OB projection neurons during development. Furthermore, neuronal and network activity in the OB, as well as the drive from the bulb to the hippocampal-prefrontal network were reduced in immune-challenged Disc1+/- mice during early development. This early deficit did not affect odor-evoked activity and odor perception but resulted in impaired long-term odor memory. We propose that reduced endogenous activity in the developing OB contributes to altered maturation of the hippocampal-prefrontal network, leading to memory impairment in immune-challenged Disc1+/- mice.