MoleculesBioinformaticsPeer-reviewed journal article
Possible transmission flow of SARS-CoV-2 based on ACE2 features
Sk. Sarif HassaniD, Shinjini GhoshiD, Diksha AttrishiD, Pabitra Pal ChoudhuryiD, Vladimir Nikolaevich UverskyiD, Bruce D. UhaliD, Kenneth H. LundstromiD, Nima RezaeiiD, Alaa A. A. AljabaliiD, Murat Seyran, Damiano PizzoliD, Parise AdadiiD, Antonio Garcia SoaresiD, Tarek Mohamed Abd El‐AziziD, Ramesh J. L. KandimallaiD, Murtaza M. TambuwalaiD, Gajendra Kumar AzadiD, Samendra P. SherchaniD, Wagner Baetas‐da‐CruziD, Kazuo TakayamaiD, Ángel Serrano‐ArocaiD, Gaurav ChauhaniD, Giorgio PalùiD, Adam BrufskyiD
Abstract
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.
- organism: human
- organism: mouse
- organism: rat
- assay: protein sequence
- research focus: protein structure prediction
- approach: statistical model
- Citations
- 35
- FWCI
- 1.05
- Field percentile
- top 12%
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