mLifeMicrobiologyPeer-reviewed journal article
An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)
L. Wei, S. Liu, S. Lu, S. Luo, X. An, H. Fan, W. Chen, E. Li, Y. Tong, L. Song
Abstract
SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) is highly attenuated, but can cause mortality in a specifically designed human ACE2-transgenic mouse model, making it an invaluable surrogate model for evaluating the efficacy of drugs and vaccines against SARS-CoV-2.
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