bioRxivNeurosciencePreprint
Alpha-Synuclein co-pathology in Alzheimer's Disease drives tau accumulation
Felix L. StruebingiD, Xiaoxuan Song, Teodoro De Vecchi, Jeannine Widmann, Federico FierliiD, Viktoria RufiD, Qilin Tang, Thomas ArzbergeriD, Sigrun Roeber, Thomas KoeglspergeriD, Otto WindliD, Amir DehsarviiD, Matthias Brendel, Nicolai FranzmeieriD, Juliane WinkelmanniD, Jochen Wolfgang HermsiD
Abstract
The molecular basis for accelerated cognitive decline seen in Alzheimers Disease (AD) cases presenting with cortical alpha-Synuclein (-Syn) co-pathology is not well understood. We show that such co-pathology brains express higher levels of microtubule-associated protein tau and that increasing -Syn expression is sufficient to drive tau accumulation. Our results reveal a hitherto unknown link between the pathogenesis of AD and Parkinsons Disease whereby tau and -Syn synergistically drive dementia-related pathology.
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