Nature CommunicationsGeneticsPeer-reviewed journal article
Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage
Jasper PanteniD, Stefania PreteiD, James ClelandiD, Lauren M. SaundersiD, Job van RietiD, Anja SchneideriD, Paul Adrian GinnoiD, Nina Schneider, Marie-Luise KochiD, Xuqi CheniD, Moritz GerstungiD, Oliver StegleiD, Arthur P. ArnoldiD, James M. A. TurneriD, Édith HeardiD, Duncan T. OdomiD
Abstract
The Four Core Genotypes (FCG) is a mouse model system heavily used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of multiple genes including the auto-immune master regulator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on FCG mice.
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