CA1 and CA3 pyramidal cell morphologies under Alzheimer’s disease Amyloid beta interaction

Alzheimers disease (AD) is a fatal neurodegenerative disorder, which imposes a growing burden on society and health systems worldwide. Remarkable, computational models for AD are rare in comparison to epilepsy and other neuropathologies. Also, neuromorphologi-cal variability in the available models is usually neglected. Here, we evaluated geometrically detailed CA1 and CA3 pyramidal neurons from rats hippocampus and its firing probability face to Amyloid-{beta} (A{beta}), a pre-plaque soluble confirmation. Such comparison is invaluable since the hippocampus acts as a structural predictor of AD progression. A stimulation protocol designed to elicit a single spike is used to access neuronal vulnerability against the A{beta} oligomers. Our experiment shows that under the same conditions there is a firing facilitation for CA3 neurons in comparison to CA1.