bioRxivNeurosciencePreprint
Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model
Eleonora Ambrad GiovannettiiD, Stefanie PolliD, Daniel JustusiD, Hiroshi KanekoiD, Falko Fuhrmann, Julia SteffeniD, Stefan RemyiD, Martin FuhrmanniD
Abstract
Disrupted neural oscillations are a feature of Alzheimers disease (AD). We observed reduced frequency of theta oscillations in the hippocampal local field potential (LFP) in a mouse model of beta-amyloidosis. By restoring the temporal organization of theta oscillations using LFP-guided closed-loop optogenetic stimulation of parvalbumin-positive interneurons, we could rescue memory deficits of APP/PS1 mice in the novel object recognition test.
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