Early-life stress-induced gut dysbiosis is ameliorated by nicotinamide treatment
Stuti SrivastaviD, Pratik Rajeev ChaudhariiD, Shital SuryavanshiiD, Nishtha PangeiD, Vidita A. VaidyaiD, Amitesh AnandiD
Abstract
Early life stress (ELS) in the form of adverse experiences in childhood results in multiple psycho-physiological pathologies during adulthood and accelerates aging. Such pathologies are recently observed to be alleviated upon nicotinamide treatment in a maternal separation model of ELS. We report a nicotinamide-driven amelioration of gut dysbiosis in middle-aged rodents with a history of neonatal maternal separation.
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