Qing Zhao

Unraveling single-molecule reactions via multiplexed in-situ DNA sequencing

This paper introduces SPIN-Seq, a method that links DNA sequence with functional properties at the single-molecule level, revealing sequence-dependent transcription factor interactions and RNA polymerase behavior.

Early-life antibiotic exposure leads to gut microbial dysbiosis associated with neurodevelopment and neuroregeneration

This study shows that early-life antibiotic exposure disrupts gut microbiota and metabolites, which negatively affect neurodevelopment and neuroregeneration in offspring.

High-throughput Single-Virion DNA-PAINT Reveals Structural Diversity, Cooperativity and Flexibility during Selective Packaging in Influenza

This study uses high-throughput DNA-PAINT to analyze influenza virus genome packaging, revealing cooperative and flexible segment interactions that guide genome assembly.

Tunable fluorogenic DNA probes drive fast and high-resolution single-molecule fluorescence imaging

The paper introduces tunable fluorogenic DNA probes that enable high-concentration single-molecule fluorescence imaging, overcoming the high concentration barrier and enabling faster and higher-resolution imaging.

USP20 deubiquitinates and stabilizes the ER-phagy receptor FAM134B to drive ER-phagy

This study identifies USP20 as a deubiquitinase that stabilizes FAM134B to drive ER-phagy under stress conditions.

Hv1 channel supports insulin secretion in pancreatic β cells through calcium entry, depolarization and intracellular pH regulation

A draft reference genome sequence for Scutellaria baicalensis Georgi

The paper reports a draft reference genome sequence for Scutellaria baicalensis using Illumina and PacBio sequencing, providing a foundation for studying its bioactive compound biosynthesis.