Xiang Zhou

Melanoma germline genetics: immune, cancer driver, and Wnt signaling genes

This paper identifies 116 risk loci for melanoma through GWAS, links susceptibility to immunity and Wnt signaling, and develops a PRS improving risk prediction.

Early-life antibiotic exposure leads to gut microbial dysbiosis associated with neurodevelopment and neuroregeneration

This study shows that early-life antibiotic exposure disrupts gut microbiota and metabolites, which negatively affect neurodevelopment and neuroregeneration in offspring.

Single-nucleus multiomic analysis reveals modulation of the gene regulatory circuit landscape in pituitary cell types during mouse estrous cycle.

The paper uses single-nucleus multiomics to study pituitary cell changes during the mouse estrous cycle, finding stage-dependent gene regulatory circuits and validated ETS2-driven gene expression patterns.

Regulation of murine follicle-stimulating hormone β subunit transcription by newly identified enhancers

The paper identifies four activin-sensitive enhancers upstream of the murine Fshb gene, showing differential regulation by SMAD2/3 and FOXL2 in gonadotropes.

Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1

This study identifies glucokinase (GCK) as a metabolic enzyme that regulates lineage plasticity in neuroendocrine prostate cancer through its interaction with AKT1.

Nanoscale Chromatin Imaging and Analysis (nano-ChIA) platform bridges 4-D chromatin organization with molecular function

The paper introduces a nano-ChIA platform that combines electron tomography and superresolution imaging to study chromatin structure and dynamics at the single-nucleosome level in live cells.

Accurate chromosome-scale haplotype-resolved assembly of human genomes

This paper introduces a method for chromosome-scale haplotype-resolved genome assembly using long reads and long-range data, achieving high accuracy and contiguity in three human genomes.

Controlling for confounding effects in single cell RNA sequencing studies using both control and target genes

This paper introduces scPLS, a method to control confounding effects in scRNA-seq by jointly modeling control and target genes, showing improved performance over existing methods.

A Unified Framework for Variance Component Estimation with Summary Statistics in Genome-wide Association Studies

This paper introduces a new framework for variance component estimation in genome-wide association studies using summary statistics, improving computational efficiency and accuracy.