PLoS Computational BiologyBioinformaticsPeer-reviewed journal article
MiDAS - Meaningful Immunogenetic Data at Scale
Maciej MigdałiD, Dan Fu RuaniD, William F. ForrestiD, Amir HorowitziD, Christian HammeriD
Abstract
Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. We present MiDAS, an R package enabling statistical association analysis and using immunogenetic data transformation functions for HLA amino acid fine mapping, analysis of HLA evolutionary divergence as well as HLA-KIR interactions. MiDAS closes the gap between inference of immunogenetic variation and its efficient utilization to make meaningful discoveries.
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- 31
- FWCI
- 2.82
- Field percentile
- top 8%
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