Maternal transmission of a paramutant phenotype requires intact DNMT2 functions in the male germline

INTRODUCTION Abstract INTRODUCTION Results DISCUSSION METHODS AND MATERIALS SUPPLEMENTARY MATERIALS Funding Author contributions Competing interests Data and materials availability Supplemental Figures REFERENCES DNA methylation, as a major epigenetic modification in the genome of higher eukaryotes, is catalyzed by DNA methyltransferase enzymes (DNMTs) by addition of a methyl group to the 5th carbon position of cytosine, resulting 5-methylcytosine (5mC) (1, 2). DNMT1 is the most abundant DNA methyltransferase in mammalian cells, and mainly methylate hemi-methylated CpG dinucleotides as a maintenance methyltransferase, although DNMT1 has also been ...