T-cell and B-cell Immunology

This study identifies MACS as a non-canonical IL-2 signaling pathway that promotes Treg differentiation and function through AP-1-dependent mechanisms.

The paper identifies a distinct B-cell lineage generated during early human lymphopoiesis that shapes antibody specificity before birth.

This study shows fever-range temperature enhances B cell function in vitro but does not improve germinal center responses or antibody production in vivo.

This study shows that TLR7-dependent autoimmunity alters intestinal immune cell dissemination, reducing lymphocytes and increasing myeloid cells, especially dendritic cells, in gut and systemic tissues.

This study shows that diacylglycerol kinases regulate B-cell development and humoral immunity by modulating DAG signaling, with distinct effects on GC B-cell homeostasis and antibody responses.

The paper identifies T-bet-expressing regulatory T cells (T-bet Tregs) as a stable regulatory subset within Th1-dendritic cell networks during type 1 inflammation.

This study shows that CD19 CAR-engineered regulatory T cells reduce B cell numbers, inflammation, and autoantibodies in lupus models, promoting long-term immune tolerance.

This study identifies tissue retention of mature dendritic cells as a driver of age-associated protective tolerogenic lymphoid structures in mice and humans.