HIV/AIDS Research and Interventions

Maternal and early-life longitudinal cytokine profiles in a South African birth cohort: the impact of HIV

This study examines cytokine profiles in HIV-exposed and unexposed children and their mothers, finding persistent immune alterations in HEU children linked to maternal HIV.

AUTO-TUNE: SELECTING THE DISTANCE THRESHOLD FOR INFERRING HIV TRANSMISSION CLUSTERS

The paper introduces a heuristic method to adaptively select a genetic distance threshold for HIV transmission network inference, demonstrating its utility in identifying clusters with different risk factors.

Modeling of HIV-1 prophylactic efficacy and toxicity with islatravir shows non-superiority for oral dosing, but promise as a subdermal implant

This paper models the efficacy and toxicity of islatravir as oral and subdermal PrEP, finding implants offer safer efficacy while oral dosing has toxicity risks.

SEPIA: Simulation-based Evaluation of Prioritization Algorithms

SEPIA evaluates prioritization algorithms for HIV transmission risk using simulations, finding ProACT slightly outperforms a distance-based method but both are only marginally better than random.

HIV Care Prioritization using Phylogenetic Branch Length

This paper introduces ProACT, a phylogenetic method for prioritizing HIV-positive individuals based on viral sequence branch lengths to improve public health resource allocation.

Drivers of HIV-1 transmission: the Portuguese case

The paper analyzes HIV-1 subtypes B and G in Portugal, finding subtype B associated with young males and active transmission clusters, while subtype G prevalence is decreasing.