Topic · Virology · Immunology and Microbiology

HIV Research and Treatment

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

SPP1+ Microglia Are Associated with Neuroimmune Rewiring and Glutamatergic Neuronal Injury in ART-Suppressed People Living with HIV

Ciniso Sylvester Shabangu, Hongjie Chen, Manickam Ashokkumar, Nikesh Katuwal, Jacob B Lovins, Edward P. Browne, Sara Gianella, Antoine Chaillon, David M. Margolis, Yuyang Tang, Guochun Jiang

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.

bioRxiv · Sep 10, 2026 · PreprintNeuroscience✦ In-depth digest

DNA origami vaccines program antigen-focused germinal centers

Anna M. Romanov, Grant A. Knappe, Larance Ronsard, Christopher A. Cottrell, Yiming J. Zhang, Heikyung Suh, Lauren Duhamel, Marjan Omer, Asheley Poole Chapman, Katie Spivakovsky, Patrick D. Skog, Claudia T. Flynn, Jeong Hyun Lee, Oleksandr Kalyuzhniy, Alessia Liguori, , Darrell J. Irvine

DNA origami particles displaying eOD-GT8 with a synthetic T helper epitope gave antigen-focused germinal centers and expanded VRC01-class precursors in humanized mice after one immunization.

Science · Feb 5, 2026Peer-reviewedImmunology✦ In-depth digest

Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models

Parham Ramezani-Rad, Christopher A. Cottrell, Ester Marina-Zárate, Alessia Liguori, Elise Landais, Jonathan L. Torres, Amber Myers, Jeong Hyun Lee, Sabyasachi Baboo, Claudia T. Flynn, Katherine R. McKenney, Eugenia Salcedo, Xiaoya Zhou, Oleksandr Kalyuzhniy, Erik Georgeson, , William R. Schief

Membrane-bound BG505 MD39.3 Env trimer delivered as mRNA-LNP reduced base-directed antibody responses in rabbits and macaques and elicited neutralizing antibodies, with memory B cell responses documented in macaques.

Science Translational Medicine · Jul 30, 2025Peer-reviewedImmunology✦ In-depth digest