Glaucoma and retinal disorders

This study shows that increasing Ucp2 expression in retinal ganglion cells protects against glaucoma-induced cell death, but transcriptional activation alone is insufficient for neuroprotection.

This study shows that deleting UCP2 in mice reduces retinal ganglion cell death in glaucoma by increasing mitophagy and mitochondrial quality control.

The paper identifies a missense variant in OLFML3 as a candidate for severe goniodysgenesis and glaucoma in Border Collies.

This study investigates the roles of MKK4 and MKK7 in retinal development and RGC death after axonal injury, finding that their deficiency increases RGC survival but disrupts retinal structure when both are absent.

This study shows that targeting complement C3 with gene therapy reduces neurodegeneration in glaucoma by protecting retinal ganglion cells.

The paper identifies a genomic locus on chromosome 8 associated with intraocular pressure (IOP) regulation in BXD RI mouse strains, with Cdh11 as the most likely candidate gene.

This study identifies a genomic locus on Chromosome 18 associated with retinal ganglion cell loss in a mouse glaucoma model.

The paper identifies a genomic locus modulating corneal thickness in mice and links it to POU6F2, a potential risk factor for glaucoma.