Richard T. Libby

The paper examines how genetic and tissue-specific factors influence the neuroinflammatory response to LPS in different brain regions of mice.

The paper develops a custom Cellpose script and models to automate RGC soma quantification and characterization in retinas.

This study shows that IL1A enhances TNF-induced retinal ganglion cell death in a SARM1-dependent manner after combined insult.

This study shows MKK4 and MKK7 drive RGC soma and axon degeneration after glaucoma injury, while DDIT3/JUN only prevent soma loss but not axon degeneration.

This study uses a 3D iPSC retina model to show that acid ceramidase deficiency causes sphingolipid metabolism changes and photoreceptor degeneration in CLN3 disease, with therapeutic potential for rhAC.

This study shows that microglia depletion in aged mice increases optic nerve damage in glaucoma models, suggesting microglia protect against ocular hypertension-induced retinal ganglion cell loss.

This study investigates the role of PP1β in neuronal function by deleting it in mice, revealing its impact on myelination, glutamate release, and action potential propagation.

This study investigates the role of DDIT3 in RGC somal loss and axonal degeneration in DBA/2J mice with chronic ocular hypertension, finding that DDIT3 contributes to somal loss but not axonal degeneration.

This study investigates the roles of MKK4 and MKK7 in retinal development and RGC death after axonal injury, finding that their deficiency increases RGC survival but disrupts retinal structure when both are absent.