Ophthalmology and Visual Impairment Studies

Increased sensitivity to myopia and altered retinal ON/OFF balance in a mouse model lacking Dusp4

This study investigates the role of Dusp4 in myopia development using a mouse model, finding altered retinal ON/OFF balance and increased sensitivity to myopia.

All-trans retinoic acid and fluid transport in myopigenesis

The paper measures all-trans retinoic acid (atRA) concentrations in mice and develops a model to understand its transport and role in myopia development.

ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB mediated signaling pathway in humans and mice

This study identifies ZC3H11A mutations as a cause of high myopia in humans and mice, showing their impact on PI3K-AKT and NF-κB signaling pathways.

Modulation of all-trans retinoic acid by light and dopamine in the murine eye

This study investigates how ambient light and dopamine affect all-trans retinoic acid levels in the mouse eye, finding that light exposure reduces atRA and that dopamine influences atRA levels.

Interactions between high-intensity light and unrestricted vision in the drive for hyperopia

The paper investigates how high-intensity light and unrestricted vision affect lens-induced hyperopia in chick eyes, finding that unrestricted vision reduces hyperopia while high-intensity light enhances it, with combined effects depending on duration.

EFEMP1 contributes to light-dependent ocular growth in zebrafish

This study shows that modifying efemp1 expression in zebrafish retina affects ocular growth and myopia development, with light-dependent effects on retinal function and molecular expression.

Establishment and comprehensive characterization of a novel dark-reared zebrafish model for myopia studies

This study establishes a dark-reared zebrafish model for myopia, showing phenotypic changes and molecular alterations linked to myopia-risk genes.

Understanding accommodative control in the clinic: modeling latency and amplitude for uncorrected refractive error, presbyopia and cycloplegia

The paper proposes a revised model of accommodative control that better predicts accommodative responses in clinical scenarios like presbyopia and cycloplegia by incorporating predictive mechanisms and gain adjustments.

Estimating the Genetic Contribution to Astigmatism and Myopia in the Mexican population

This study estimates the genetic contribution to astigmatism and myopia in the Mexican population using twin data and finds high heritability and genetic correlations.

Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population

This study identifies low-frequency variants in FKBP5 and FOLH1 associated with high myopia in Han Chinese and European populations through whole-exome sequencing and functional experiments.

Recovery from form-deprivation myopia in chicks is dependent upon the fullness and correlated colour temperature of the light spectrum

This study shows that full-spectrum Sunlike-LEDs accelerate recovery from form-deprivation myopia in chicks compared to fluorescent lights, possibly through choroidal and scleral changes.

Ablation of mpeg+ macrophages exacerbates mfrp-related hyperopia

This study shows that ablating mpeg+ macrophages worsens mfrp-related hyperopia in zebrafish, suggesting macrophages help mitigate hyperopia.

Visually Induced Changes in Cytokine Production in the Chick Choroid

The paper shows that IL-6 is upregulated in chick choroids under myopic conditions and is influenced by nitric oxide, suggesting a role in visually guided ocular growth.

Genetic network regulating visual acuity makes limited contribution to visually guided eye emmetropization

The paper investigates the role of the retinal genetic network regulating visual acuity in visually guided eye emmetropization and finds it has a limited contribution.

Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection

The paper uses genome-wide RNA-seq to analyze retinal genetic networks involved in contrast perception and optical defocus detection, revealing their role in myopia development.

Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia

The paper identifies genes and pathways regulating refractive eye development in mice and links them to human myopia, revealing distinct genetic networks for baseline development and environmental susceptibility.

Human Foveal Cone Photoreceptor Topography and its Dependence on Eye Length

The paper measures foveal cone density in relation to axial length in living eyes and finds that myopes have higher angular sampling density despite retinal stretching.

Inverse occlusion, a binocularly motivated treatment for amblyopia

This study shows that short-term inverse occlusion improves binocular balance, visual acuity, and stereo acuity in adults and older children with amblyopia.