Mycotoxins in Agriculture and Food

Opposing immunomodulatory effects of the Alternaria mycotoxin tenuazonic acid in immune and intestinal epithelial cells

This study examines how tenuazonic acid affects immune and intestinal epithelial cells, showing opposing immunomodulatory effects depending on cell type.

Modulation of NF-κB signaling by Alternaria mycotoxins: in vitro and in silico insights into molecular mechanisms of immunosuppression in THP-1 monocytes

This study investigates how Alternaria mycotoxins modulate NF-κB signaling in THP-1 monocytes using in vitro experiments and in silico docking analyses, revealing toxin-specific effects on inflammatory responses.

Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling

The paper predicts human internal exposure to alternariol and AME using a PBK model, finding concentrations far below toxic thresholds.

Culmorin inhibits detoxification of the mycotoxin deoxynivalenol by plant UDP-glucosyltransferases

This study shows that culmorin inhibits plant UDP-glucosyltransferases, reducing detoxification of the mycotoxin deoxynivalenol and enhancing Fusarium virulence.

Mycotoxin-driven proteome remodeling reveals limited activation of Triticum aestivum responses to emerging chemotypes integrated with fungal modulation of ergosterols

This study examines proteome changes in wheat and Fusarium graminearum in response to 15ADON/3ANX mycotoxins, identifying chemotype-specific proteins and fungal virulence factors.

Spatial Metabolomics Reveals the Role of Penicillic Acid in Cheese Rind Microbiome Disruption by a Spoilage Fungus

This paper identifies how Aspergillus westerdijkiae uses penicillic acid and other metabolites to inhibit cheese rind bacteria, disrupting microbial communities through chemical interactions.

Role of the osaA transcription factor gene in development, secondary metabolism and virulence in the mycotoxigenic fungus Aspergillus flavus

This study identifies osaA as a key transcription factor in Aspergillus flavus regulating aflatoxin production, morphological development, and pathogenicity, suggesting it as a target for controlling mycotoxin contamination.

Proteomic Changes in the Cytoplasmatic Fraction of Weaned Piglets Liver and Kidney Under Antioxidants and Mycotoxins Diets

This study examines how antioxidants from grape seed and sea buckthorn meal affect proteomic changes in liver and kidney cytoplasm of weaned piglets exposed to mycotoxins.

Impact of Mycotoxins and Glyphosate residue on the Gut Microbiome and Resistome of European Fallow Deer

This study examines how mycotoxins and glyphosate residues affect the gut microbiome and resistome of European fallow deer, finding changes in bacterial communities and antibiotic resistance genes.

Ecophysiological Behaviour Of Major Fusarium Species In Response To Combinations Of Temperature And Water Activity Constraints

This study examines how five major Fusarium species respond to temperature and water activity, showing significant interspecific variation in growth and mycotoxin production.

The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B

This study identifies Beauvericin as an uncompetitive inhibitor of Cathepsin B through NMR, enzyme kinetics, and molecular docking analyses in dendritic cells.

The study on the impact of indoleacetic acid on enhancing the ability of the rumen's original microecology to degrade aflatoxin B1.

This study investigates how indoleacetic acid (IAA) enhances the rumen microecology's ability to degrade aflatoxin B1, showing improved degradation rates and microbial stability.

Phosphorylation of Zearalenone retains its toxicity

This study investigates the toxicity of phosphorylated Zearalenone derivatives and finds they retain cytotoxic, pro-inflammatory, and estrogenic properties.

The Fusarium graminearum transporters Abc1 and Abc6 are important for xenobiotic resistance, trichothecene accumulation, and virulence to wheat.

This study shows that deletion of ABC transporters Abc1 and Abc6 in Fusarium graminearum reduces trichothecene accumulation and virulence on wheat.

Inferring the presence of aflatoxin-producing Aspergillus flavus strains using RNA sequencing and electronic probes as a transcriptomic screening tool

The paper develops EDNAtran, a tool to detect aflatoxin-related gene expression in transcriptomic data using e-probes, showing significant differences in corn samples compared to non-aflatoxin-producing samples.